Intracellular pathogens and chronic infections
At NL-Lab, we conduct research on bacteria that entrench themselves in the white blood cell. These so-called intracellular pathogens can cause chronic inflammation and infection and can lead to long-term vague symptoms such as fatigue, loss of concentration, muscle pain, joint pain and headaches.
A chronic infection often begins with an acute infection due to a variety of possible causes, ranging from a tick bite, a cat scratch, a wound, or a sore throat.
Chronic infectious disease progresses slowly and often has prolonged periods of indistinct disease symptoms. These symptoms may lurk for months or years (e.g., in tuberculosis).
Chronic infectious diseases are usually more difficult to diagnose than acute infections. As a result, damage can be high before long-term treatment is instituted.
White blood cells are programmed to fight inflammation. They eliminate any damaged or infected cells. Once the damage from this acute infection is controlled and the initial symptoms have passed, the white blood cells die off or go back to doing what they did before: being ready to respond to new injury.
Chronic inflammation occurs when the cause of the infection, such as a bacterium, finds a chance to entrench itself in the white blood cell. Here the bacteria can vegetate and eventually multiply without our immune system being able to do anything about it. After all, the pathogen is located ín a part of the immune system: the white blood cell.
In this way, the pathogens are very difficult to trace and can spread throughout the body and cause vague symptoms such as fatigue, loss of concentration, muscle pain, joint pain and headaches everywhere.
Pathogens we can detect
NL-Lab has developed research methods to detect these pathogens in their "hiding" form:
- Aeromonas hydrophila
- Anaplasma species
- Babesia species
- Bartonella species
- Bordetella pertussis
- Borrelia burgdorferi
- Borrelia species
- Chlamydia pneumoniae
- Chlamydia trachomatis
- Ehrlichia species
- Haemophilus influenzae
- Mycobacterium tuberculosis
- Mycobacterium species
- Mycoplasma pneumoniae
- Porphyromonas gingivalis
- Propionibacterium acnes
- Pseudomonas aeruginosa
- Rickettsia species
- Salmonella enterica
- Salmonella species
- Staphylococcus aureus
- Staphylococcus species
- Streptococcus species
Tick-bite diseases / Lyme disease
The best-known tick-borne disease is Lyme disease, or Lyme Borreliosis, an infection caused by the Borrelia bacteria. The most common Borrelia species is Borrelia burgdorferi, but several, other species occur throughout the world. These bacteria are transmitted through the bite of a tick. In addition to the possibility of ticks carrying several Borrelia species, a tick can also be infected with many other bacteria, viruses, parasites and other microorganisms harmful to humans. Any of these microorganisms, when transmitted, can lead to illness, and in most cases this manifests itself in fever some time after the tick bite.
Chronic symptoms in Lyme disease
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