Intracellular pathogens and chronic infections

At NL-Lab, we conduct research on bacteria that entrench themselves in the white blood cell. These so-called intracellular pathogens can cause chronic inflammation and infection and can lead to long-term vague symptoms such as fatigue, loss of concentration, muscle pain, joint pain and headaches.

The cause can vary. One of the best known is a tick bite and Lyme disease. But we are able to detect many more pathogens.

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Chronic infections

A chronic infection often begins with an acute infection due to a variety of possible causes, ranging from a tick bite, a cat scratch, a wound, or a sore throat.

Chronic infectious disease progresses slowly and often has prolonged periods of indistinct disease symptoms. These symptoms may lurk for months or years (e.g., in tuberculosis).

Chronic infectious diseases are usually more difficult to diagnose than acute infections. As a result, damage can be high before long-term treatment is instituted.

White blood cells are programmed to fight inflammation. They eliminate any damaged or infected cells. Once the damage from this acute infection is controlled and the initial symptoms have passed, the white blood cells die off or go back to doing what they did before: being ready to respond to new injury.

Chronic inflammation occurs when the cause of the infection, such as a bacterium, finds a chance to entrench itself in the white blood cell. Here the bacteria can vegetate and eventually multiply without our immune system being able to do anything about it. After all, the pathogen is located ín a part of the immune system: the white blood cell.

In this way, the pathogens are very difficult to trace and can spread throughout the body and cause vague symptoms such as fatigue, loss of concentration, muscle pain, joint pain and headaches everywhere.

Pathogens we can detect

NL-Lab has developed research methods to detect these pathogens in their "hiding" form:

  • Aeromonas hydrophila
  • Anaplasma species
  • Babesia species
  • Bartonella species
  • Bordetella pertussis
  • Borrelia burgdorferi
  • Borrelia species
  • Chlamydia pneumoniae
  • Chlamydia trachomatis
  • Ehrlichia species
  • Haemophilus influenzae
  • Mycobacterium tuberculosis
  • Mycobacterium species
  • Mycoplasma pneumoniae
  • Porphyromonas gingivalis
  • Propionibacterium acnes
  • Pseudomonas aeruginosa
  • Rickettsia species
  • Salmonella enterica
  • Salmonella species
  • Staphylococcus aureus
  • Staphylococcus species
  • Streptococcus species

Tick-bite diseases / Lyme disease

The best-known tick-borne disease is Lyme disease, or Lyme Borreliosis, an infection caused by the Borrelia bacteria. The most common Borrelia species is Borrelia burgdorferi, but several, other species occur throughout the world. These bacteria are transmitted through the bite of a tick. In addition to the possibility of ticks carrying several Borrelia species, a tick can also be infected with many other bacteria, viruses, parasites and other microorganisms harmful to humans. Any of these microorganisms, when transmitted, can lead to illness, and in most cases this manifests itself in fever some time after the tick bite.

Chronic symptoms in Lyme disease

According to the RIVM, over 1 million people are bitten by a tick each year in the Netherlands. About 2 in 100 people contract Lyme disease after the tick bite, about 27,000 people a year. The nature and severity of symptoms in patients with Lyme disease vary. The vast majority of people who contract the disease develop a distinctive ring or spot at the site of the tick bite. In addition, 1,200 to 1,500 people annually develop joint complaints, skin complaints, nerve complaints or heart complaints. This large group of disorders is grouped under the term "Tick-bite Diseases. Diseases in this group are characterized by diversity in symptomatology but can all take on a chronic phase. Of the 27,000 patients, an estimated 1,000 to 2,500 people per year maintain long-term symptoms. In that case, one speaks of "chronic Lyme disease.

Interested?

Our blood test can only be ordered through a practitioner. If you are an individual, please contact us and we can refer you. Are you a practitioner? Sign up without obligation.

Why choose NL-Lab?

Rich and unique data thanks to our superior C-FISH analysis method.

Smart interpretation of measured data, thanks to proprietary models, protocols and methods.

Scientifically-substantiated therapeutic advice consistent with practice.

Customer-friendly support: easily accessible and personal.

Reliable: Scientifically based, validated and independent.

And much more! Discover the many benefits of NL-Lab.

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